Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression
نویسندگان
چکیده
Orit Jacobson1+, Ido D. Weiss2+, Lu Wang3, Zhe Wang1, Xiangyu Yang1, Andrew Dewhurst1, Ying Ma1, Guizhi Zhu1, Gang Niu1, Dale O. Kiesewetter1, Neil Vasdev3, Steven H. Liang3* and Xiaoyuan Chen1* 1Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering; and 2Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases; National Institutes of Health, Bethesda, MD, USA. 3Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital & Department of Radiology, Harvard Medical School, Boston, MA, USA
منابع مشابه
18F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression.
UNLABELLED Protein tyrosine kinase-7 (PTK7), a member of receptor tyrosine kinase superfamily initially identified as colon carcinoma kinase-4, is highly expressed in various human malignancies. Its expression was found to correlate with aggressive biologic behaviors such as increased cell proliferation, invasiveness, and migration. Despite the importance and unmet need of imaging PTK7 in vivo,...
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تاریخ انتشار 2015